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ORIGINAL ARTICLE
Year : 2018  |  Volume : 43  |  Issue : 2  |  Page : 49-54

High expression of activation-induced cytidine deaminase mRNA can predict early-stage progression and poor responsiveness to treatment in chronic lymphocytic leukemia


1 Department of Hematology, Medical Research Institute, Alexandria University, Alexandria, Egypt
2 Department of Clinical Pathology, Military Medical Academy, Cairo, Egypt

Correspondence Address:
Mohamed A.M El-Menoufy
Hematology Department, Medical Research Institute, Alexandria University, Alexandria 21561
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_35_17

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Background Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease. Some patients exhibit an indolent disease without requiring therapy, whereas others show rapidly progression and die within months. The Rai and Binet staging systems are unable to predict disease progression in the early stages. Aim The aim of this study was to evaluate the clinical value of activation-induced cytidinedeaminase (AID) mRNA expression in predicting disease progression in early stages and response to therapy in later stages of CLL. Patients and Methods We assessed AID mRNA expression by quantitative real-time PCR in 42 patients with B-CLL. Results High AID expression was associated with shorter duration for the need to start antileukemic treatment in patients with earlystage CLL. Moreover, high AID expression was also found in patients not achieving complete remission or nonresponding to treatment. Conclusion AID could be used to predict early disease progression and was shown to be relevant in predicting responsiveness to antileukemic treatment in CLL cases.


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