• Users Online: 279
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2013  |  Volume : 38  |  Issue : 1  |  Page : 47-50

Role of T-helper 17 cells and interleukin-17 expression in patients with acute myeloid leukemia

1 Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Clinical Hematology and Bone Marrow Transplant Unit, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Mona A Ismail
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University Hospitals, Ramses St, Abbassia, Cairo 11566
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.7123/01.EJH.0000423016.44965.49

Rights and Permissions


Several observations suggest that immunological events are important for antileukemic immune reactivity in acute myeloid leukemia (AML). T-helper type 17 (Th17) cells play an active role in inflammatory and autoimmune diseases; however, the nature of Th17 cells in hematological malignancies remains unknown.


The aim of this work was to assess the role of Th17 cells and its related cytokine interleukin-17 (IL-17) in the pathogenesis and prognosis of AML.

Participants and methods

The study was carried out on 40 adult AML patients and 20 age-matched and sex-matched controls. Patients were diagnosed and classified according to the WHO criteria for AML. Plasma levels of IL-17 in patients and controls were measured using the sandwich ELISA technique. Th17 cells were assessed using flow cytometry.


The percentage of Th17 cells and the concentration of IL-17 were significantly increased in untreated patients with AML compared with the healthy controls (10.2±2.2 vs. 4.38±0.16% and 20.15±2.9 vs. 8.2±1.3 pg/ml, respectively). In addition, the increased Th17 cells were reduced significantly when the patient achieved complete remission after chemotherapy, but the decrease was not significant in patients with incomplete remission.


These results suggest that Th17 cells play a role in the pathogenesis and response of therapy in AML patients through the secretion of IL-17 cytokine.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded146    
    Comments [Add]    

Recommend this journal