• Users Online: 207
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2014  |  Volume : 39  |  Issue : 2  |  Page : 64-67

Study of MEFV gene R202Q polymorphism in Egyptian patients with familial Mediterranean fever

1 Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Pediatrics, Suez Canal University, Ismailia, Egypt

Correspondence Address:
Lobna O ElMessery
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo 11399
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-1067.139764

Rights and Permissions

Familial Mediterranean fever (FMF) is a hereditary disorder characterized by recurrent attacks of fever and serositis. Several mutations in the MEFV gene have been associated with the disease. The aim of the present study is to investigate the frequency of the R202Q(605G>A) polymorphism in exon 2 of the MEFV gene and its clinical significance in a cohort of Egyptian patients with FMF. The study included 55 FMF patients and 40 healthy controls. The polymorphism was tested using polymerase chain reaction (PCR) based restriction fragment length polymorphism (RFLP). The genotype and allele frequency was similar in patients and controls. No significant association was found between demographic and clinical characteristics of patients and R202Q genotype. Further studies covering wider geographical areas in Egypt are required to reveal the diagnostic relevance of this molecular marker in Egypt.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded195    
    Comments [Add]    

Recommend this journal