• Users Online: 195
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 43  |  Issue : 2  |  Page : 49-54

High expression of activation-induced cytidine deaminase mRNA can predict early-stage progression and poor responsiveness to treatment in chronic lymphocytic leukemia

1 Department of Hematology, Medical Research Institute, Alexandria University, Alexandria, Egypt
2 Department of Clinical Pathology, Military Medical Academy, Cairo, Egypt

Correspondence Address:
Mohamed A.M El-Menoufy
Hematology Department, Medical Research Institute, Alexandria University, Alexandria 21561
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejh.ejh_35_17

Rights and Permissions

Background Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease. Some patients exhibit an indolent disease without requiring therapy, whereas others show rapidly progression and die within months. The Rai and Binet staging systems are unable to predict disease progression in the early stages. Aim The aim of this study was to evaluate the clinical value of activation-induced cytidinedeaminase (AID) mRNA expression in predicting disease progression in early stages and response to therapy in later stages of CLL. Patients and Methods We assessed AID mRNA expression by quantitative real-time PCR in 42 patients with B-CLL. Results High AID expression was associated with shorter duration for the need to start antileukemic treatment in patients with earlystage CLL. Moreover, high AID expression was also found in patients not achieving complete remission or nonresponding to treatment. Conclusion AID could be used to predict early disease progression and was shown to be relevant in predicting responsiveness to antileukemic treatment in CLL cases.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded168    
    Comments [Add]    

Recommend this journal