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Year : 2019  |  Volume : 44  |  Issue : 2  |  Page : 111-117

Outcome of reduced-intensity allogeneic stem cell transplantation in Egyptian patients with myelodysplastic syndromes

1 Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
2 Department of Clinical Pathology, Clinical Hematology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt
3 Department of Internal Medicine, Clinical Hematology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt
4 Department of Oncological Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
5 Department of Medical Oncology, South Cancer Institute, Assiut University, Assiut, Egypt

Correspondence Address:
Safinaz Hussein
Clinical Hematology, Department of Internal Medicine, Assiut University, Assiut, 71516
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejh.ejh_2_19

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Background Reduced-intensity conditioning for allogeneic stem cell transplantation (allo-SCT) is possible for patients with myelodysplasia syndrome (MDS) who are ineligible for high-dose myeloablative conditioning allo-SCT. Objective To determine the outcome of reduced-intensity allo-SCT in Egyptian patients with MDS. Patients and methods A total of 18 patients with MDS were included, and the median age was 39 years. The conditioning regimen consisted of fludarabine (150 mg/m2) and busulfan (8 mg/kg). All patients received mobilized peripheral blood stem cells. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. Results The Kaplan–Meier-estimated 2-year overall survival and disease-free survival were 49 and 33%, respectively. The Kaplan–Meier-estimated probability of relapse at 2 years was 43.5%. The Kaplan–Meier-estimated probability of nonrelapse mortality at 2 years was 43%, and severe acute GVHD and sepsis were the main causes of death. The Kaplan–Meier-estimated probabilities of acute and chronic GVHD were 31 and 20%, respectively. Conclusion Although reduced-intensity conditioning regimens allowed for decreased transplant-related toxicities and increased durable engraftments, their use was associated with a high incidence of relapse in patients with MDS.

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