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Year : 2019  |  Volume : 44  |  Issue : 3  |  Page : 163-167

The role of human monocyte-expressing markers (CD163 and MR/CD206) in pediatric sepsis

1 Clinical Pathology Department, Faculty of Medicine, Assiut University, Asyut, Egypt
2 Pediatric Department, Asyut, Egypt

Correspondence Address:
Eman NasrEldin
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Asyut, 7111
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejh.ejh_24_19

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Background The diagnosis of pediatric sepsis requires sensitive biomarkers to start effective prompt treatment. We evaluated the significance of the haptoglobin–hemoglobin receptor (CD163) and the mannose receptor (MR/CD206) expression and their soluble serum levels as early diagnostic markers for pediatric sepsis. Patients and methods This prospective study investigated 50 pediatric patients suspected of having sepsis and 50 age-matched healthy control children. Detection of monocyte expression of CD163 and MR was analyzed by flow cytometric technique, and the soluble serum levels of CD163 and MR were determined by enzyme-linked immunosorbent assay. The diagnostic values of the monocytes’ related markers were assessed using the area under the receiver operating characteristic (AUROC) curve. Results The monocyte expression of CD163 and MR/CD206 and their serum levels were significantly higher in the septic patients than in the controls. We show that the sensitivity of sMR to predict sepsis exceeded that of either C-reactive protein or procalcitonin (area under the curve= 0.98, 0.86, and 0.82, respectively). sMR had higher area under the curve than soluble macrophage-related protein 163 [0.93; 95% confidence interval (CI): 0.79–0.98] followed by monocyte-bound CD163 expression (0.77; 95% CI: 0.61–0.93) and then MR/CD206 (0.68; 95% CI: 0.56–0.90). Conclusion The study supports the important significance of the monocyte/macrophage-related markers for prediction of sepsis in children and highlights the potential diagnostic use of their soluble forms as new pediatric sepsis biomarkers.

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