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ORIGINAL ARTICLE
Year : 2020  |  Volume : 45  |  Issue : 3  |  Page : 121-128

GRAF gene expression in patients with acute and chronic myeloid leukaemia: impact on the prognosis


1 Department of Clinical Pathology, Benha University, Benha, Egypt
2 Department of Clinical Pathology, Mansoura University, Mansoura, Egypt

Correspondence Address:
Deena A El-Shabrawy
Department of Clinical Pathology, Benha University, Benha
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_31_17

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Objective We aimed to assess the expression level of GRAF gene in patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) and to clarify its prognosticsignificance on the clinical outcome. Background GTPase regulator associated with focal adhesion kinase (GRAF) is a newly identified protein specifically binding to focal adhesion kinase and negatively regulates the small GTP-binding protein RhoA, which is well known for its growth-promoting effect in RAS-mediated malignant transformation. GRAF is recognized as a tumor suppressor gene that binds to focal adhesion kinase. Methods In this study, we investigated the expression of the GRAF transcript by realtime quantitative PCR in 37 AML patients, 35 CML patients and 15 healthy and sex-matched controls, and to clarify its prognostic significance on the clinical outcome. Results We found that the GRAF expression is low in patients with AML and CML. A high GRAF expression is a favorable prognostic marker in patients with AML and CML. In AML, high GRAF transcript. Conclusion High GRAF expression is a favorable prognostic marker in AML patients and a protective factor against CML progression.


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