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Year : 2020  |  Volume : 45  |  Issue : 3  |  Page : 136-141

Protein Z measurement in acute myeloid leukemia patients

Department of Internal Medicine and Clinical Hematology, Ain Shams Universiy, Cairo, Egypt

Correspondence Address:
Haydi S Mohamed
Lecturer of Internal Medicine and Clinical Hematology, Ain Shams University, Cairo, 11813
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejh.ejh_58_19

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Background Protein Z (PZ) is a vitamin K-dependent plasma protein. The role of PZ in the pathogenesis of hemostatic disorders remains to be established. However, a significant association was found between low PZ levels and arterial vascular diseases, pregnancy complications and disseminated intravascular coagulation, stroke and antiphospholipid syndrome. On the other hand, it has been suggested that PZ deficiency is associated with hemorrhagic disorders, perhaps related to capillary fragility. Aim Measurement of the level of PZ in newly diagnosed acute myeloid leukemia (AML) patients and correlate it with bleeding tendency or thrombosis. Patients and methods This study was held on 90 participants divided into 60 adult (AML) patients and 30 healthy controls of matched age and sex from the Internal Medicine Department, Ain Shams University Hospital. Enzyme-linked immunosorbent assay kits are used for the estimation of PZ levels after taking informed consent. Results A low level of PZ was detected in AML patients compared with controls (P<0.001). A statistical correlation was observed between bleeding attacks and PZ level (P=0.008). The best cutoff value for PZ as a predictor for bleeding was more than 350 ng/l by the receiver operating characteristic curve. Conclusion Low PZ level is a cofactor of bleeding in AML patients.

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