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Year : 2020  |  Volume : 45  |  Issue : 3  |  Page : 156-159

Serum and salivary ferritin levels in iron-deficiency anemia − is there a difference?

1 Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
MD Amr M Gawaly
Department of Internal Medicine, Faculty of Medicine, El Gish Street, Tanta, 9111
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejh.ejh_23_20

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Introduction Iron-deficiency anemia (IDA) is one of the most important nutritional deficiencies in Egypt. The assessment of serum ferritin has been the gold standard method in the detection of this disease However, this involves the drawing of venous blood, which is invasive and is sometimes physically and psychologically traumatic to the patients, and sometimes it is difficult to withdraw blood from hidden veins. This study was done to estimate and correlate serum ferritin levels and saliva ferritin levels of patients with IDA, thus assessing the effectiveness of saliva as an alternative noninvasive diagnostic tool. This study was done to estimate, compare, and correlate the ferritin levels in serum and saliva of patients with IDA, to determine whether saliva can be used as a predictive marker to monitor the iron levels in IDA. Patients and methods A total of 60 patients with IDA and 20 healthy participants as control were chosen for the study. Quantitative estimation of serum and salivary ferritin levels was performed by solid-phase ELISA. Hemoglobin levels were also estimated to confirm the anemic status of the patient. Data were statistically analyzed using SPSS software version 19. Results There was increased salivary ferritin level in patients with IDA. A negative significant correlation was found between serum hemoglobin and both salivary ferritin level and salivary/serum ferritin ratio, and a significant negative correlation between serum and salivary ferritin levels. Conclusion Salivary ferritin is a noninvasive method for the detection of IDA with a good predictive effect.

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